Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

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Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity.Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.Directing the use of DDR kinase inhibitors in cancer treatment.

P2860

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P2860

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

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http://www.wikidata.org/entity/Q38261022

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2015 nî lūn-bûn

@nan

2015年の論文

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2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

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2015年學術文章

@zh-hant

name

Mdm2 inhibition confers protec ...... xic effects of Wee1 inhibitors

@en

type

Item

label

Mdm2 inhibition confers protec ...... xic effects of Wee1 inhibitors

@en

prefLabel

Mdm2 inhibition confers protec ...... xic effects of Wee1 inhibitors

@en

P1476

Mdm2 inhibition confers protec ...... xic effects of Wee1 inhibitors

@en

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Anusha Sriraman

http://www.w3.org/2001/XMLSchema#string

Priyanka Saini

http://www.w3.org/2001/XMLSchema#string

Yizhu Li

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

WAF1, a potential mediator of p53 tumor suppression

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Participation of p53 protein in the cellular response to DNA damage

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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32339-32352

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scholarly article

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10.18632/ONCOTARGET.5891

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English

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http://www.w3.org/2001/XMLSchema#string

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http://www.w3.org/2001/XMLSchema#string

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Matthias Dobbelstein

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2015-09-29T00:00:00Z

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282569345

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P698

26431163

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P921

cytotoxicity

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4741697

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Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

about

P2860

P2860

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

description

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type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932