Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.
about
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingKDM1 class flavin-dependent protein lysine demethylasesProtein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.Identification of JL1037 as a novel, specific, reversible lysine-specific demethylase 1 inhibitor that induce apoptosis and autophagy of AML cellsLSD1: biologic roles and therapeutic targeting.Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Inhibitors of Protein Methyltransferases and Demethylases.Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia.Epigenetic therapy approaches in non-small cell lung cancer: Update and perspectives.A chemical probe toolbox for dissecting the cancer epigenome.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells.LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth.Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock.LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in cancer cells.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migrationPreclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutationsDifferentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells
P2860
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P2860
Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
@zh-hant
name
Reversible inhibitors of LSD1 ...... ificance and progress to date.
@en
type
label
Reversible inhibitors of LSD1 ...... ificance and progress to date.
@en
prefLabel
Reversible inhibitors of LSD1 ...... ificance and progress to date.
@en
P2093
P2860
P356
P1476
Reversible inhibitors of LSD1 ...... ificance and progress to date.
@en
P2093
Alison E McGonagle
Allan M Jordan
Emma L Williams
P2860
P304
P356
10.1002/MED.21334
P577
2014-11-24T00:00:00Z