Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. - Wikidata - wikimedia - TriplyDB

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.

http://www.wikidata.org/entity/Q38281336

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Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance Targeting the Hedgehog Pathway in Pediatric Medulloblastoma Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions The Role of Hedgehog Signaling in Tumor Induced Bone Disease The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer.Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug.Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy.Aberrant methylation of the PTCH1 gene promoter region in aberrant crypt foci.Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion.Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy.Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model.Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells.A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma.Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1 RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition Hedgehog signaling and radiation induced liver injury: a delicate balance.Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination.Hedgehog signaling in prostate cancer and its therapeutic implication A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells.Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells.Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo.Recent advances in the therapeutic applications of pyrazolines.Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors.The utility of hedgehog signaling pathway inhibition for cancer.Hedgehog signaling pathway and cancer therapeutics: progress to date.

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P2860

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.

http://www.wikidata.org/entity/Q38281336

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

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name

Blocking Hedgehog survival sig ...... n human colon carcinoma cells.

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type

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Blocking Hedgehog survival sig ...... n human colon carcinoma cells.

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Blocking Hedgehog survival sig ...... n human colon carcinoma cells.

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Blocking Hedgehog survival sig ...... n human colon carcinoma cells.

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Akwasi Agyeman

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Janet A Houghton

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Jennifer Devecchio

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Tapati Mazumdar

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Ting Shi

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P2860

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

The DNA damage response: putting checkpoints in perspective

Gli proteins encode context-dependent positive and negative functions: implications for development and disease

DNA double-strand breaks: signaling, repair and the cancer connection

Cyclin A in cell cycle control and cancer

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

Hedgehog signaling in animal development: paradigms and principles

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

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