Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. - Wikidata - wikimedia - TriplyDB

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

http://www.wikidata.org/entity/Q38287490

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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.RNAi-mediated inhibition of Lgr5 leads to decreased angiogenesis in gastric cancer.The physiological impact of the serum and glucocorticoid-inducible kinase SGK1 Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival.LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity.IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.Immediate early response gene X-1, a potential prognostic biomarker in cancers Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis.Ets2 regulates colonic stem cells and sensitivity to tumorigenesis.The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses.Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts.Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling.Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer.Defining the role of TRIP6 in cell physiology and cancer.Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.Identifying novel protein complexes in cancer cells using epitope-tagging of endogenous human genes and affinity-purification mass spectrometry.mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation.Transcriptional analysis of left-sided colitis, pancolitis, and ulcerative colitis-associated dysplasia.Going with the Wnt? Focus on "Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC".Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia.Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas

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Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

http://www.wikidata.org/entity/Q38287490

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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Putative direct and indirect W ...... adenomas from humans and mice.

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Human Molecular Genetics

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Putative direct and indirect W ...... adenomas from humans and mice.

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Andrew Rowan

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Andrew Silver

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Bradley Spencer-Dene

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Emma Nye

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Gordon Stamp

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Maesha Deheragoda

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Mohammad Ilyas

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Nirosha Suraweera

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Phil East

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Richard Poulsom

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P2860

The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein

Identification of stem cells in small intestine and colon by marker gene Lgr5

Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells.

Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations.

Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.

Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors.

APC, signal transduction and genetic instability in colorectal cancer.

Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

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3864-3875

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10.1093/HMG/DDN286

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24

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17

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18782851

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