Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
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Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans developmentEffect of Dietary Restriction and Subsequent Re-Alimentation on the Transcriptional Profile of Bovine Skeletal MusclePAS kinase is required for normal cellular energy balanceTwo modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycleTissue expression profiles and transcriptional regulation of elongase of very long chain fatty acid 6 in bovine mammary epithelial cells.Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies.Genetic control of de novo lipogenesis: role in diet-induced obesityELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolismA novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects.Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesityPolymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cellsMonocyte to macrophage differentiation goes along with modulation of the plasmalogen pattern through transcriptional regulation.Epigenetic regulation of the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) SignalingCryptosporidium parvum long-chain fatty acid elongase.Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.Fatty acid and transcriptome profiling of longissimus dorsi muscles between pig breeds differing in meat qualityTissue-specific, nutritional, and developmental regulation of rat fatty acid elongases.Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate compositionHepatic and plasma sex differences in saturated and monounsaturated fatty acids are associated with differences in expression of elongase 6, but not stearoyl-CoA desaturase in Sprague-Dawley rats.Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats.Analysis of miRNAs and their target genes associated with lipid metabolism in duck liver.Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in miceFatty acid chain-elongation in perfused rat heart: synthesis of stearoylcarnitine from perfused palmitate.Genetic analysis of the ELOVL6 gene polymorphism associated with type 2 diabetes mellitus.Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat's liverFatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression.Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis.
P2860
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P2860
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
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2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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name
Cloning and characterization o ...... ic enzyme regulated by SREBPs.
@en
type
label
Cloning and characterization o ...... ic enzyme regulated by SREBPs.
@en
prefLabel
Cloning and characterization o ...... ic enzyme regulated by SREBPs.
@en
P2093
P921
P1476
Cloning and characterization o ...... nic enzyme regulated by SREBPs
@en
P2093
Akimitsu Takahashi
Alyssa H Hasty
Hiroaki Okazaki
Hitoshi Shimano
Jun-Ichi Osuga
Ken Ohashi
Michiyo Amemiya-Kudo
Nobuhiro Yamada
Shigeru Yato
Shun Ishibashi
P304
P577
2002-06-01T00:00:00Z