Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
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ELOVL5 mutations cause spinocerebellar ataxia 38Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 miceInduced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesisTwo modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycleWhole genome transcript profiling of drug induced steatosis in rats reveals a gene signature predictive of outcomeThe Genetic Architecture of Murine Glutathione TransferasesELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in miceClinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38)Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP arrayFatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J miceRole of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid speciesRetinal very long-chain PUFAs: new insights from studies on ELOVL4 proteinElongase reactions as control points in long-chain polyunsaturated fatty acid synthesis.Saturated fats: a perspective from lactation and milk compositionMetabolism of very long-chain Fatty acids: genes and pathophysiology.Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice.Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosisDogs and humans share a common susceptibility gene SRBD1 for glaucoma risk.The role of fatty acid elongation in epidermal structure and function.Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study.Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liverModulation of lipid metabolism in glycyrrhizic acid-treated rats fed on a high-calorie diet and exposed to short or long-term stress.Health implications of high dietary omega-6 polyunsaturated Fatty acids.The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid.Fatty acid regulation of hepatic lipid metabolism.The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells.The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humansInduced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities.Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesisChronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis.Omega-3 fatty acid supplementation and cardiovascular disease.Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese miceCommon genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis.Genome-wide association studies for fatty acid metabolic traits in five divergent pig populationsEicosanoids in metabolic syndrome.Fatty acid metabolism: Implications for diet, genetic variation, and disease.Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat's liver
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Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
@en
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
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type
label
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
@en
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
@nl
prefLabel
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
@en
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
@nl
P2093
P2860
P1476
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
@en
P2093
Jay D Horton
Robert E Hammer
Young-Ah Moon
P2860
P304
P356
10.1194/JLR.M800383-JLR200
P577
2008-10-06T00:00:00Z