Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3.
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HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticityIncreased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cellsMast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3GATA-3 is required for early T lineage progenitor developmentA gene regulatory network armature for T lymphocyte specification.Progression of regulatory gene expression states in fetal and adult pro-T-cell development.GATA-3 dose-dependent checkpoints in early T cell commitment.From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.E proteins and the regulation of early lymphocyte developmentSall4 overexpression blocks murine hematopoiesis in a dose-dependent manner.Lineage plasticity and commitment in T-cell development.Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene.Signatures of human regulatory T cells: an encounter with old friends and new playersAt the crossroads: diverse roles of early thymocyte transcriptional regulators.Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.Transcriptional regulation of lymphocyte developmentId1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression.Eliciting the T cell fate with Notch.Multilayered specification of the T-cell lineage fate.T cell lineage commitment: identity and renunciation.Transcriptional control of early T and B cell developmental choicesTranscriptional regulation of early T-cell development in the thymus.Hematopoiesis and T-cell specification as a model developmental system.GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development.GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fateThe development of T cells from stem cells in mice and humans.Transcription factor expression dynamics of early T-lymphocyte specification and commitment.Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingHEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.The roles of miR-146a in the differentiation of Jurkat T-lymphoblasts.Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor.
P2860
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P2860
Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Definition of regulatory netwo ...... analysis with PU.1 and GATA-3.
@en
type
label
Definition of regulatory netwo ...... analysis with PU.1 and GATA-3.
@en
prefLabel
Definition of regulatory netwo ...... analysis with PU.1 and GATA-3.
@en
P2093
P356
P1476
Definition of regulatory netwo ...... analysis with PU.1 and GATA-3.
@en
P2093
Alexandra M Arias
Christopher J Dionne
Gabriela Hernandez-Hoyos
P304
P356
10.1006/DBIO.2002.0674
P407
P577
2002-06-01T00:00:00Z