Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.
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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesImpaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folatesReduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heartBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair associationExpression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activitiesTherapeutic strategies targeting proteins that regulate folate and reduced folate transport.Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells.Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida.Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.Resistance to antifolates.The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.Gene-nutrient interactions: importance of folic acid and vitamin B12 during early embryogenesis.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Structural organization of the reduced folate carrier gene in Chinese hamster ovary cells.Interaction of rhubarb and methotrexate in rats: in vivo and ex vivo approaches.Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates.Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12.The H(+)-dependent reduced folate carrier 1 of humans and the sodium-dependent methotrexate carrier-1 of the rat are orthologs.Functional role of arginine 373 in substrate translocation by the reduced folate carrier.Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.Mutations in the reduced-folate carrier affect protein localization and stability.A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells.Neural tube and craniofacial defects with special emphasis on folate pathway genes.Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function.Cancer chemotherapy: targeting folic acid synthesis.Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons.Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothiMutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.
P2860
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P2860
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Characterization of a mutation ...... 210 murine leukemia cell line.
@en
type
label
Characterization of a mutation ...... 210 murine leukemia cell line.
@en
prefLabel
Characterization of a mutation ...... 210 murine leukemia cell line.
@en
P2093
P2860
P356
P1476
Characterization of a mutation ...... 210 murine leukemia cell line.
@en
P2093
E E Sierra
I D Goldman
K E Brigle
M J Spinella
P2860
P304
22974-22979
P356
10.1074/JBC.270.39.22974
P407
P577
1995-09-01T00:00:00Z