Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance - Wikidata - wikimedia - TriplyDB

Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

http://www.wikidata.org/entity/Q38292045

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The ABCs of Candida albicans Multidrug Transporter Cdr1 Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution Xenobiotic efflux in bacteria and fungi: a genomics update Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Genetic Basis of Antifungal Drug Resistance Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicans An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans UPC2 is universally essential for azole antifungal resistance in Candida albicans.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.Prediction of phenotype-associated genes via a cellular network approach: a Candida albicans infection case study Inhibition of Candida albicans by Fluvastatin Is Dependent on pH.Disruption of the transcriptional regulator Cas5 results in enhanced killing of Candida albicans by Fluconazole Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1.The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans.Using SCOPE to identify potential regulatory motifs in coregulated genes.In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.Transcription factor ADS-4 regulates adaptive responses and resistance to antifungal azole stress Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans.A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans Identification of the Candida albicans Cap1p regulon.Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans.Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi.Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.Transcription factor CCG-8 as a new regulator in the adaptation to antifungal azole stress.The global regulator Ncb2 escapes from the core promoter and impacts transcription in response to drug stress in Candida albicans.Medically important fungi respond to azole drugs: an update.Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans.The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen.From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2.Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells Antifungal resistance and new strategies to control fungal infections.Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency.Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.

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Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

http://www.wikidata.org/entity/Q38292045

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Eukaryotic Cell

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Genomewide location analysis o ...... lism and azole drug resistance

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François Robert

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Martine Raymond

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Osman Zin Al-Abdin

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Perrine Bomme

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Saloua Saidane

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Sandra Weber

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Simon Drouin

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Sébastien Lemieux

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Xavier De Deken

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P2860

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.

Mapping pathways and phenotypes by systematic gene overexpression.

Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae.

A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae.

Identifying transcription factor functions and targets by phenotypic activation.

SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells.

Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae.

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.

Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor.

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836-847

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10.1128/EC.00070-08

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5

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7

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5461213

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18390649

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2394978

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