An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans
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The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways.Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonTriclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformansThe transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansResistance Mechanisms and Clinical Features of Fluconazole-Nonsusceptible Candida tropicalis Isolates Compared with Fluconazole-Less-Susceptible IsolatesERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis.UPC2 is universally essential for azole antifungal resistance in Candida albicans.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.In vivo systematic analysis of Candida albicans Zn2-Cys6 transcription factors mutants for mice organ colonization.Regulatory circuitry governing fungal development, drug resistance, and disease.Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosityRegulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Milestones in Candida albicans gene manipulation.Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans.A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.Milbemycins: more than efflux inhibitors for fungal pathogensCrystallization and preliminary X-ray crystallographic analysis of sterol transcription factor Upc2 from Saccharomyces cerevisiae.The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression.Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factorDistinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulenceAzole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species.Medically important fungi respond to azole drugs: an update.Plasma membrane lipids and their role in fungal virulence.Antifungals: Mechanism of Action and Drug Resistance.Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoterThe development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen.Ploidy dynamics and evolvability in fungiFluconazole resistance in Candida species: a current perspective.From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2.Antifungal resistance and new strategies to control fungal infections.A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans.Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains.Candida parapsilosis Resistance to Fluconazole: Molecular Mechanisms and In Vivo Impact in Infected Galleria mellonella Larvae.Genomewide expression profile analysis of the Candida glabrata Pdr1 regulon.An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.Regulation of the hypoxic response in Candida albicans.Transcriptional profiling of azole-resistant Candida parapsilosis strainsLoss of heterozygosity at an unlinked genomic locus is responsible for the phenotype of a Candida albicans sap4Δ sap5Δ sap6Δ mutant.Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1.
P2860
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P2860
An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
An A643T mutation in the trans ...... resistance in Candida albicans
@ast
An A643T mutation in the trans ...... resistance in Candida albicans
@en
An A643T mutation in the trans ...... esistance in Candida albicans.
@nl
type
label
An A643T mutation in the trans ...... resistance in Candida albicans
@ast
An A643T mutation in the trans ...... resistance in Candida albicans
@en
An A643T mutation in the trans ...... esistance in Candida albicans.
@nl
prefLabel
An A643T mutation in the trans ...... resistance in Candida albicans
@ast
An A643T mutation in the trans ...... resistance in Candida albicans
@en
An A643T mutation in the trans ...... esistance in Candida albicans.
@nl
P2093
P2860
P356
P1476
An A643T mutation in the trans ...... resistance in Candida albicans
@en
P2093
Clemens J Heilmann
Joachim Morschhäuser
Katherine S Barker
P David Rogers
Sabrina Schneider
P2860
P304
P356
10.1128/AAC.01102-09
P407
P577
2009-11-02T00:00:00Z