MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
about
3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) geneGenome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling dataLeukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expressionCBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesisHoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cellsHOXA5-twist interaction alters p53 homeostasis in breast cancer cellsThe PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesisThe role of FLT3 in haematopoietic malignanciesNew insight into the molecular mechanisms of MLL-associated leukemiaALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemiasStructural and functional alterations of FLT3 in acute myeloid leukemiaGlobal and Hox-specific roles for the MLL1 methyltransferaseGene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationAltered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemiaHoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalizationIdentification and characterization of Hoxa9 binding sites in hematopoietic cellsRegulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalizationConstitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemiaOn the epistemological crisis in genomicsMicroarrays and molecular markers for tumor classificationInter-species differences of co-expression of neighboring genes in eukaryotic genomesA combinational feature selection and ensemble neural network method for classification of gene expression dataInter-platform comparability of microarrays in acute lymphoblastic leukemiaA HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomasEnhanced microarray performance using low complexity representations of the transcriptomeSearching for differentially expressed gene combinations.Microarray missing data imputation based on a set theoretic framework and biological knowledgeEmerging technologies in paediatric leukaemiaThe complexity of epigenetic diseasesEmerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysMicroRNA-regulated pathways in hematological malignancies: how to avoid cells playing out of tuneClustering cancer gene expression data: a comparative studyTargeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesTargeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and TreatmentB-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expressionPerspectives on the causes of childhood leukemiaMisguided transcriptional elongation causes mixed lineage leukemia
P2860
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P2860
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
MLL translocations specify a d ...... stinguishes a unique leukemia.
@en
type
label
MLL translocations specify a d ...... stinguishes a unique leukemia.
@en
prefLabel
MLL translocations specify a d ...... stinguishes a unique leukemia.
@en
P2093
P50
P356
P1433
P1476
MLL translocations specify a d ...... stinguishes a unique leukemia.
@en
P2093
Jane E Staunton
Lewis B Silverman
Mark D Minden
Scott A Armstrong
Stanley J Korsmeyer
Stephen E Sallan
Todd R Golub
P2888
P356
10.1038/NG765
P407
P577
2001-12-03T00:00:00Z