The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. - Wikidata - wikimedia - TriplyDB

The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer.

The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer.

http://www.wikidata.org/entity/Q38294813

about

Transglutaminase is a tumor cell and cancer stem cell survival factor Tissue transglutaminase as a central mediator in inflammation-induced progression of breast cancer Epigenome-based personalized medicine in human cancer High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells Unraveling breast cancer heterogeneity through transcriptomic and epigenomic analysis.Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR.Transglutaminase regulation of cell function.Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium.EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.TGM2: a cell surface marker in esophageal adenocarcinomas.Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma.Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma.GPR56 in cancer progression: current status and future perspective.Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway TRIM29 suppresses TWIST1 and invasive breast cancer behavior.Bisulfite sequencing of DNA.Transglutaminase 2: a molecular Swiss army knife.Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.Genome-wide analysis of DNA methylation and expression of microRNAs in breast cancer cells.RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis.Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.Tissue transglutaminase-interleukin-6 axis facilitates peritoneal tumor spreading and metastasis of human ovarian cancer cells.Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.Epigenetic targeting in breast cancer: therapeutic impact and future direction.Aberrant promoter CpG methylation and its translational applications in breast cancer.Transglutaminase 2 and NF-κB: an odd couple that shapes breast cancer phenotype.Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches.Transglutaminase 2 in cancer.The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia.Oxidative stress shapes breast cancer phenotype through chronic activation of ATM-dependent signaling.Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target.Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways.Expression of transglutaminase-2 isoforms in normal human tissues and cancer cell lines: dysregulation of alternative splicing in cancer.ATM is required for SOD2 expression and homeostasis within the mammary gland.The transglutaminase 2 gene is aberrantly hypermethylated in glioma Identification of differentially expressed genes regulated by molecular signature in breast cancer-associated fibroblasts by bioinformatics analysis.CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer.

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The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer.

http://www.wikidata.org/entity/Q38294813

description

2008 nî lūn-bûn

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The transglutaminase 2 gene (T ...... lly silenced in breast cancer.

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Berna Demircan

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Kevin D Brown

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Kevin J Bray

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Lingbao Ai

http://www.w3.org/2001/XMLSchema#string

Lisa M Dyer

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Nicole A Massoll

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Ryan R Skehan

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Wan-Ju Kim

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GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis

Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

CpG islands in vertebrate genomes

Tissue cells feel and respond to the stiffness of their substrate

DNA methylation and human disease

Methylation-induced repression--belts, braces, and chromatin

Tissue transglutaminase: an enzyme with a split personality.

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510-518

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10.1093/CARCIN/BGM280

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3

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29

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18174247

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