Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2
about
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsDNA mismatch repair: molecular mechanism, cancer, and ageingEarly Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damageHuman MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repairNuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint.Targeting and processing of site-specific DNA interstrand crosslinks.Human pluripotent stem cells have a novel mismatch repair-dependent damage response.Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.DNA damage during reoxygenation elicits a Chk2-dependent checkpoint responseATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.CHK2 kinase in the DNA damage response and beyondExonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements.Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancerDNA mismatch repair and the DNA damage response.Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer.MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine.NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair.Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro.MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea.Drug-sensitive DNA polymerase δ reveals a role for mismatch repair in checkpoint activation in yeast.Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses.MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine.Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway.Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells.DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage.
P2860
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P2860
Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2
description
2005 nî lūn-bûn
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2005 թուականի Մարտին հրատարակուած գիտական յօդուած
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2005 թվականի մարտին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@ast
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@en
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@nl
type
label
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@ast
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@en
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@nl
prefLabel
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@ast
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@en
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@nl
P2093
P2860
P356
P1476
Methylator-induced, mismatch r ...... ctivated through Chk1 and Chk2
@en
P2093
Aaron W Adamson
Dillon I Beardsley
Kevin D Brown
R Baskaran
Wan-Ju Kim
Yajuan Gao
P2860
P304
P356
10.1091/MBC.E04-02-0089
P407
P577
2005-03-01T00:00:00Z