WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.
about
The zinc finger domain of Wilms' tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cellsCiao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosisA novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomesA novel WT1 heterozygous nonsense mutation (p.K248X) causing a mild and slightly progressive nephropathy in a 46,XY patient with Denys-Drash syndromeOrganizing principles of mammalian nonsense-mediated mRNA decayPar4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesisA zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndromeThe Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron.In silico regulatory analysis for exploring human disease progression.The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Antagonism of WT1 activity by protein self-association.A novel WT1 gene mutation in a three-generation family with progressive isolated focal segmental glomerulosclerosis.Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferationThe Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.Molecular genetics of chromosome translocations involving EWS and related family members.The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells.Clinical and molecular characterization of patients with heterozygous mutations in wilms tumor suppressor gene 1.Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms.Insights into the physiological role of WT1 from studies of genetically modified mice.WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis.Tumor suppressor genetics.The role of VEGF 165b in pathophysiologySp1 is a critical regulator of the Wilms' tumor-1 gene.RNA binding by the Wilms tumor suppressor zinc finger proteins.Identification of connective tissue growth factor as a target of WT1 transcriptional regulation.Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control.A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling.Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter.Bilateral Wilms tumor in a boy with severe hypospadias and cryptochidism due to a heterozygous mutation in the WT1 gene.Wilms tumor gene expression in acute myeloid leukemias.Regulation of the Wilms' tumour suppressor protein transcriptional activation domain.Internal translation initiation generates novel WT1 protein isoforms with distinct biological properties.Exploring the role of homeobox and zinc finger proteins in pancreatic cell proliferation, differentiation, and apoptosis.The Wilms tumour gene WT1 in leukaemia.
P2860
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P2860
WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
WT1-mediated transcriptional a ...... nant negative mutant proteins.
@en
type
label
WT1-mediated transcriptional a ...... nant negative mutant proteins.
@en
prefLabel
WT1-mediated transcriptional a ...... nant negative mutant proteins.
@en
P2093
P2860
P356
P1476
WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins
@en
P2093
P2860
P304
10878-10884
P356
10.1074/JBC.270.18.10878
P407
P577
1995-05-01T00:00:00Z