A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.
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Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformationsEvidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutationsThe nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal capsControl of pancreas and liver gene expression by HNF transcription factorsPancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas developmentHyperinsulinemic Hypoglycemia - The Molecular MechanismsEpistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alphaMacrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A geneShort and long-term impact of lipectomy on expression profile of hepatic anabolic genes in rats: a high fat and high cholesterol diet-induced obese modelFunctions of HNF1 family members in differentiation of the visceral endoderm cell lineageGenetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice.Type 2 diabetes: hypoinsulinism, hyperinsulinism, or both?Improved conditional expression systems resulting in physiological level of HNF4alpha expression confirm HNF4alpha induced apoptosis in the pancreatic beta-cell line INS-1.Genetic epidemiology of diabetes.Dissecting the transcriptional network of pancreatic islets during development and differentiation.Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity.Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes.Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.Prediabetes is associated with HNF-4 α P2 promoter polymorphism rs1884613: a case-control study in Han Chinese population and an updated meta-analysisGenetic approaches to the molecular understanding of type 2 diabetes.Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell functionHepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youthA systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites.Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy MetabolismTranscriptional Regulation of the Pancreatic Islet: Implications for Islet Function.Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.Functional analyses of the mutation nt-128 T→G in the hepatocyte nuclear factor-1α promoter region in Chinese diabetes pedigrees.Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell FunctionIdentification of a novel beta-cell glucokinase (GCK) promoter mutation (-71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humansRNA processing and mRNA surveillance in monogenic diabetes.Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.Messenger RNA processing and its role in diabetes.Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networksComprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi.Hepatocyte nuclear factor-4 mediates apolipoprotein A-IV transcriptional regulation by fatty acid in newborn swine enterocytes.Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.
P2860
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P2860
A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
A distant upstream promoter of ...... y-onset diabetes of the young.
@en
type
label
A distant upstream promoter of ...... y-onset diabetes of the young.
@en
prefLabel
A distant upstream promoter of ...... y-onset diabetes of the young.
@en
P2093
P356
P1476
A distant upstream promoter of ...... y-onset diabetes of the young.
@en
P2093
Frayling TM
Hattersley AT
Jaschkowitz K
Lingott-Frieg A
Mitchell SM
P304
P356
10.1093/HMG/10.19.2089
P577
2001-09-01T00:00:00Z