Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. - Wikidata - wikimedia - TriplyDB

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

http://www.wikidata.org/entity/Q38297724

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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter Nuclear export-independent inhibition of Foxa2 by insulin Drosophila tools and assays for the study of human diseases The human plasma lipidome Genetically modified mouse models for the study of nonalcoholic fatty liver disease Genome-wide association analyses for fatty acid composition in porcine muscle and abdominal fat tissues A cardiac microRNA governs systemic energy homeostasis by regulation of MED13 Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.Using pre-existing microarray datasets to increase experimental power: application to insulin resistance.Molecular mechanisms involved in hepatic steatosis and insulin resistance.Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity.Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition.Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice.Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes.Genetic control of de novo lipogenesis: role in diet-induced obesity Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species High-fat diet leads to tissue-specific changes reflecting risk factors for diseases in DBA/2J mice.ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production.Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects.Lipid-induced insulin resistance: unravelling the mechanism.Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting Metabolism of very long-chain Fatty acids: genes and pathophysiology.De Novo Lipogenesis Products and Endogenous Lipokines.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.

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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

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2007 nî lūn-bûn

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Crucial role of a long-chain f ...... ty-induced insulin resistance.

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Crucial role of a long-chain f ...... ty-induced insulin resistance.

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Crucial role of a long-chain f ...... ity-induced insulin resistance

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Akimitsu Takahashi

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Ayaka Atsumi

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Hideo Toyoshima

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Hiroaki Suzuki

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Hitoshi Iwasaki

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Hitoshi Shimano

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Jun-ichi Osuga

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Ken Ohashi

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Mayumi Ishikawa

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Motohiro Sekiya

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10.1038/NM1662

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