Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesisLipoexpediency: de novo lipogenesis as a metabolic signal transmitterNuclear export-independent inhibition of Foxa2 by insulinDrosophila tools and assays for the study of human diseasesThe human plasma lipidomeGenetically modified mouse models for the study of nonalcoholic fatty liver diseaseGenome-wide association analyses for fatty acid composition in porcine muscle and abdominal fat tissuesA cardiac microRNA governs systemic energy homeostasis by regulation of MED13Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiologySexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in miceTwo modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycleGaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.Using pre-existing microarray datasets to increase experimental power: application to insulin resistance.Molecular mechanisms involved in hepatic steatosis and insulin resistance.Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity.Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J miceDietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition.Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice.Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes.Genetic control of de novo lipogenesis: role in diet-induced obesityGlycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid speciesHigh-fat diet leads to tissue-specific changes reflecting risk factors for diseases in DBA/2J mice.ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolismAltered desaturation and elongation of fatty acids in hormone-sensitive lipase null miceA diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production.Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects.Lipid-induced insulin resistance: unravelling the mechanism.Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fastingMetabolism of very long-chain Fatty acids: genes and pathophysiology.De Novo Lipogenesis Products and Endogenous Lipokines.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.
P2860
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P2860
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Crucial role of a long-chain f ...... ty-induced insulin resistance.
@en
type
label
Crucial role of a long-chain f ...... ty-induced insulin resistance.
@en
prefLabel
Crucial role of a long-chain f ...... ty-induced insulin resistance.
@en
P2093
P50
P921
P356
P1433
P1476
Crucial role of a long-chain f ...... ity-induced insulin resistance
@en
P2093
Akimitsu Takahashi
Ayaka Atsumi
Hideo Toyoshima
Hiroaki Suzuki
Hitoshi Iwasaki
Hitoshi Shimano
Jun-ichi Osuga
Ken Ohashi
Mayumi Ishikawa
Motohiro Sekiya
P2888
P304
P356
10.1038/NM1662
P407
P577
2007-09-30T00:00:00Z