Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.
about
Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA AffinityHsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activityIntracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein InteractionsStabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.The delivery of therapeutic oligonucleotidesReduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents.Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides.2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF.Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides.Managing the sequence-specificity of antisense oligonucleotides in drug discovery.Specific Increase of Protein Levels by Enhancing Translation Using Antisense Oligonucleotides Targeting Upstream Open Frames.Electronic Structures of LNA Phosphorothioate Oligonucleotides.Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotidesCTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.Molecular Mechanisms of Antisense Oligonucleotides.Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides.Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs.BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA).Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus.COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways
P2860
Q27708987-E3F7AD88-9A1A-4BDF-B7B8-EBC3E1AF3BA7Q28833550-E7DD17EE-69A1-45F2-B96C-9676B7247127Q33786263-193DD53F-2D43-403C-8031-45954953DFC1Q36115825-F9BEA83C-C791-4575-BD97-D07F75016D68Q36775577-88697865-1A53-4247-94CD-A1C3373E532BQ37210936-82D6B5CF-C4E5-4A78-BDE2-7D6923CE326DQ37723428-B48C6D53-0EFE-4619-B40A-F882E34D402FQ38291806-E98A6D2C-C426-4A31-9F78-48E1946A4F5BQ38299896-F2E71DA1-79A8-4DCD-8133-9BDFF3FD2E3CQ38669913-28F74EFD-9920-42D0-BF27-5D22E1ADF80EQ38828951-842295E8-340E-479E-B221-B7DDA38E57BBQ39390082-A3972519-C986-48C7-8619-C8DBF8F40B8DQ41192925-A5D94B75-6026-4340-AE37-477407AFAC90Q41693957-455BE1EC-FA31-4910-A7CB-6DB3378748B8Q42258984-E8B25254-CF86-4BDB-BAE5-EED309AB630EQ42293314-C2AA26E9-D0D6-4BE5-A6BF-FF6073083762Q46286420-F89E57D6-5E73-4B60-BF5C-B4F3BBB97D9DQ47134784-C40C0301-F2A8-462C-8B98-6ED7FA510590Q47374105-7E156B82-C680-434C-92E8-ED15E3EF32E1Q47884385-7D786141-9755-402F-91B4-8AFFD2987768Q49489377-1B381026-3425-4019-98C7-CC95327CE8B1Q49830924-EA33EC3A-6311-4A51-BF7A-AAE4FC83DF3FQ50100050-1D4C1925-055E-43F1-B13A-C62021B69AE6Q50101001-C26A8FCA-28C2-4B8E-BAE9-512700EFCF6EQ51743392-C334DFD9-B30D-4E71-8326-27F66D69580EQ52764171-3787175D-9539-4935-A30F-065F86DD9F94Q58708488-DC5ECC8D-F75B-455F-B356-45CFB0A022DA
P2860
Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Identification and characteriz ...... ith phosphorothioate linkages.
@en
type
label
Identification and characteriz ...... ith phosphorothioate linkages.
@en
prefLabel
Identification and characteriz ...... ith phosphorothioate linkages.
@en
P2093
P2860
P356
P1476
Identification and characteriz ...... ith phosphorothioate linkages.
@en
P2093
Stanley T Crooke
Xue-hai Liang
P2860
P304
P356
10.1093/NAR/GKV143
P407
P577
2015-02-20T00:00:00Z