Role of the p53-homologue p73 in E2F1-induced apoptosis.
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Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damageRunt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivityInduction of p57(KIP2) expression by p73beta.TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survivalE2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferasesIrofulven induces replication-dependent CHK2 activation related to p53 statusThe transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiationSelection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA library(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2E2F1 in melanoma progression and metastasisSelective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylationp73 as a pharmaceutical target for cancer therapyFunction of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Non-thermal atmospheric pressure plasma preferentially induces apoptosis in p53-mutated cancer cells by activating ROS stress-response pathways.E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.E2F3 is a mediator of DNA damage-induced apoptosis.Tumor suppression by p53: making cells senescent.p63 and p73 in tumor suppression and promotion.Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells.Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoterE2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.ARF mutation accelerates pituitary tumor development in Rb+/- mice.Role of p73 in malignancy: tumor suppressor or oncogene?Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapyRecombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 proteinE2F1 pathways to apoptosis.Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ationp53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALSThe p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain.p73 in Cancer.Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c
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P2860
Role of the p53-homologue p73 in E2F1-induced apoptosis.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Role of the p53-homologue p73 in E2F1-induced apoptosis.
@en
type
label
Role of the p53-homologue p73 in E2F1-induced apoptosis.
@en
prefLabel
Role of the p53-homologue p73 in E2F1-induced apoptosis.
@en
P2860
P356
P1433
P1476
Role of the p53-homologue p73 in E2F1-induced apoptosis.
@en
P2093
B M Pützer
P2860
P2888
P304
P356
10.1038/82617
P407
P577
2000-12-01T00:00:00Z