Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.
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Cys-140 is critical for metabotropic glutamate receptor-1 dimerizationCrystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolutionHuman interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity bindingInsights into cytokine-receptor interactions from cytokine engineeringActivating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signallingThe serine protease TMPRSS6 is required to sense iron deficiencySeeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cellsActive conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains.Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexesErythropoietin and erythropoietin receptor.Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface.Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domainJanus kinases: components of multiple signaling pathways.Erythropoietin in human milk: physiology and role in infant health.Chimeric tumor necrosis factor receptors with constitutive signaling activity.Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.Drugs for increasing oxygen and their potential use in doping: a review.Mimicry of erythropoietin by a nonpeptide moleculeMechanistic diversity of cytokine receptor signaling across cell membranes.Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways.Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.A proliferation switch for genetically modified cells.Loss of functional cell surface transforming growth factor beta (TGF-beta) type 1 receptor correlates with insensitivity to TGF-beta in chronic lymphocytic leukemia.PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.Understanding cytokine and growth factor receptor activation mechanisms.Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway.Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D.Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development.Erythropoietin: elucidating new cellular targets that broaden therapeutic strategiesMultiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy.Erythropoietin and oxidative stress.Hematopoietic cytokine receptor signaling.Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cellsA sequential dimerization mechanism for erythropoietin receptor activationA chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo
P2860
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P2860
Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Activation and inhibition of e ...... role of receptor dimerization.
@en
type
label
Activation and inhibition of e ...... role of receptor dimerization.
@en
prefLabel
Activation and inhibition of e ...... role of receptor dimerization.
@en
P2860
P356
P1476
Activation and inhibition of e ...... role of receptor dimerization.
@en
P2093
D J Hilton
S S Watowich
P2860
P304
P356
10.1128/MCB.14.6.3535
P407
P577
1994-06-01T00:00:00Z