Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. - Wikidata - wikimedia - TriplyDB

Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins.

Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins.

http://www.wikidata.org/entity/Q38309150

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Broad-spectrum antiviral therapeutics Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein Improved NYVAC-based vaccine vectors Vaccinia virus E3 protein prevents the antiviral action of ISG15 Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway Functional analysis of the short isoform of orf virus protein OV20.0.Comparative analysis of poxvirus orthologues of the vaccinia virus E3 protein: modulation of protein kinase R activity, cytokine responses, and virus pathogenicity Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC.Lost in the world of functional genomics, systems biology, and translational research: is there life after the Milstein award?Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes.Function of RIG-I-like receptors in antiviral innate immunity.Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling A Z-DNA sequence reduces slipped-strand structure formation in the myotonic dystrophy type 2 (CCTG) x (CAGG) repeat Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus.Attenuated NYCBH vaccinia virus deleted for the E3L gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways.Monkeypox virus and insights into its immunomodulatory proteins.Involvement of the cellular phosphatase DUSP1 in vaccinia virus infection.Vaccinia virus vaccines: past, present and future.Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways.Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication Silencing suppressors: viral weapons for countering host cell defenses.The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus.Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus Human Cytomegalovirus pTRS1 and pIRS1 Antagonize Protein Kinase R To Facilitate Virus Replication.Regulation of vaccinia virus E3 protein by small ubiquitin-like modifier proteins.Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1.Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein.The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon beta.Immunogenicity of recombinant vaccinia virus vaccines co-expressing GP3/GP5 of European PRRSV and Cap protein of PCV2 in pigs.Poxvirus Host Range Genes and Virus-Host Spectrum: A Critical Review.

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P2860

Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins.

http://www.wikidata.org/entity/Q38309150

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2006 nî lūn-bûn

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name

Suppression of proinflammatory ...... e vaccinia virus E3L proteins.

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type

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Suppression of proinflammatory ...... e vaccinia virus E3L proteins.

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Suppression of proinflammatory ...... e vaccinia virus E3L proteins.

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Journal of Virology

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Suppression of proinflammatory ...... e vaccinia virus E3L proteins.

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P2093

Bertram L Jacobs

http://www.w3.org/2001/XMLSchema#string

Jeffrey O Langland

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John C Kash

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Matthew J Thomas

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Victoria Carter

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P2860

Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation

Complex regulation of the human gene for the Z-DNA binding protein DLM-1.

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

Innate immune recognition of viral infection

Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection

The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA

Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

A role for Z-DNA binding in vaccinia virus pathogenesis

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

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10083-10095

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10.1128/JVI.00607-06

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17005686

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