Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
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Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.TYK2 is a key regulator of the surveillance of B lymphoid tumorsActivation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoproteinIL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cellsRole of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesisNecdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancerIcariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signalingAG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathwayPhosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformationActivation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro.Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replicationIndirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cellsEnhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src.Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors.Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation.A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cellsRegulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor.The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activityJak2 is involved in c-Myc induction by Bcr-Abl.STAT proteins: novel molecular targets for cancer drug discovery.6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.The role of prolactin in mammary carcinoma.Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomasThe role of Tyk2 in regulation of breast cancer growth.A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processesING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivoHyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells.STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinomaSignal transducers and activators of transcription: insights into the molecular basis of oral cancer.Age-associated chronic diseases require age-old medicine: role of chronic inflammation.STAT3 mediates resistance to MEK inhibitor through microRNA miR-17.JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signalingHydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells.G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation.
P2860
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P2860
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Activation of Stat3 in v-Src-t ...... ation of Jak1 kinase activity.
@en
type
label
Activation of Stat3 in v-Src-t ...... ation of Jak1 kinase activity.
@en
prefLabel
Activation of Stat3 in v-Src-t ...... ation of Jak1 kinase activity.
@en
P2093
P2860
P356
P1476
Activation of Stat3 in v-Src-t ...... ation of Jak1 kinase activity.
@en
P2093
A Levitzki
C Carter-Su
J J Krolewski
T Smithgall
P2860
P304
24935-24944
P356
10.1074/JBC.M002383200
P407
P577
2000-08-01T00:00:00Z