Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
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Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferaseStructures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor bindingFunctional analysis of an acid adaptive DNA adenine methyltransferase from Helicobacter pylori 26695Coupling sequence-specific recognition to DNA modification.Study of bacteriophage T4-encoded Dam DNA (adenine-N6)-methyltransferase binding with substrates by rapid laser UV cross-linking.Pre-steady state kinetics of bacteriophage T4 dam DNA-[N(6)-adenine] methyltransferase: interaction with native (GATC) or modified sites.Metadynamics simulation study on the conformational transformation of HhaI methyltransferase: an induced-fit base-flipping hypothesisA dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase.AdoMet-dependent methylation, DNA methyltransferases and base flipping.Control of catalytic cycle by a pair of analogous tRNA modification enzymes.Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase.Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases.Linking epigenetic function to electrostatics: The DNMT2 structural model exampleCavitation as a mechanism of substrate discrimination by adenylosuccinate synthetasesDNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.DNA methyltransferases: mechanistic models derived from kinetic analysis.Water-assisted dual mode cofactor recognition by HhaI DNA methyltransferase.Bacteriophage T4 Dam DNA-[N6-adenine]methyltransferase. Kinetic evidence for a catalytically essential conformational change in the ternary complex.The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase.Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins.Differential stabilization of reaction intermediates: specificity checkpoints for M.EcoRI revealed by transient fluorescence and fluorescence lifetime studies.Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferaseMutational analysis of conserved residues in HhaI DNA methyltransferasePreferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.Transient kinetics of the reaction catalysed by magnesium protoporphyrin IX methyltransferase.Oligomerization of DNMT3A controls the mechanism of de novo DNA methylationObserving an induced-fit mechanism during sequence-specific DNA methylation.The coupling of tight DNA binding and base flipping: identification of a conserved structural motif in base flipping enzymes.Kinetic and catalytic properties of dimeric KpnI DNA methyltransferase.DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam.Bacteriophage T4Dam (DNA-(adenine-N6)-methyltransferase): evidence for two distinct stages of methylation under single turnover conditions.Functional characterization of Escherichia coli DNA adenine methyltransferase, a novel target for antibiotics.Residues distal from the active site that alter enzyme function in M.HhaI DNA cytosine methyltransferase.Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine.
P2860
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P2860
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
@en
type
label
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
@en
prefLabel
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
@en
P2093
P2860
P356
P1476
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase.
@en
P2093
Lindstrom WM Jr
P2860
P304
P356
10.1074/JBC.275.7.4912
P407
P577
2000-02-01T00:00:00Z