Activation of DNA-dependent protein kinase by single-stranded DNA ends.
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwaySynapsis of DNA ends by DNA-dependent protein kinasep53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.Processing of DNA for nonhomologous end-joining by cell-free extractDifferential activation of DNA-PK based on DNA strand orientation and sequence biasTerminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis.Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.DNA-PK autophosphorylation facilitates Artemis endonuclease activityDNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining systemThe mechanism of human nonhomologous DNA end joiningConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageActivation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins.Postcleavage sequence specificity in V(D)J recombination.DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.Activation of the immune system by bacterial CpG-DNA.ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining.Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ.Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?Repair of double-strand breaks by end joining.DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends.Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.Synthesis of virus-specific high-mobility DNA after temperature upshift of SC-1 cells chronically infected with moloney murine leukemia virus mutant ts1.Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs.Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase.Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions.DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
P2860
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P2860
Activation of DNA-dependent protein kinase by single-stranded DNA ends.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Activation of DNA-dependent protein kinase by single-stranded DNA ends.
@en
type
label
Activation of DNA-dependent protein kinase by single-stranded DNA ends.
@en
prefLabel
Activation of DNA-dependent protein kinase by single-stranded DNA ends.
@en
P2093
P2860
P356
P1476
Activation of DNA-dependent protein kinase by single-stranded DNA ends.
@en
P2093
P2860
P304
P356
10.1074/JBC.275.3.1541
P407
P577
2000-01-01T00:00:00Z