The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
about
TLR2 controls intestinal carcinogen detoxication by CYP1A1The evolving role of the aryl hydrocarbon receptor (AHR) in the normophysiology of hematopoiesisXenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicityDioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylationDioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzymeEnvironmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response elementInduction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptorTranscriptome profiling of Chironomus kiinensis under phenol stress using Solexa sequencing technologyDioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesisUroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant miceToward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locusDopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat LiverIn vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed ratsFor dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequentialModulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementationNonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessmentIntensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experimentsHuman response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancerGenetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues.Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice.Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene.Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity.Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor.Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis.A QSAR evaluation of Ah receptor binding of halogenated aromatic xenobioticsImmunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patientsBinding of polychlorinated biphenyls to the aryl hydrocarbon receptor.The Environmental Genome Project: functional analysis of polymorphisms.Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.Generation of a new congenic mouse strain with enhanced chymase expression in mast cells.Genetic architecture of susceptibility to PCB126-induced developmental cardiotoxicity in zebrafish.Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice.Cytochrome P450: what have we learned and what are the future issues?Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in miceImmunotoxic effects of exposure of rats to xenobiotics via maternal lactation. Part I 2,3,7,8-tetrachlorodibenzo-p-dioxinCross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.
P2860
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P2860
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
@en
type
label
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
@en
prefLabel
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
@en
P2860
P1476
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
@en
P2093
D W Nebert
P2860
P304
P356
10.3109/10408448909017908
P407
P577
1989-01-01T00:00:00Z