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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia BStructure and function of legumain in health and diseaseCoagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate bindingThe 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognitionStructure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffoldCrystal structure of the tricorn protease reveals a protein disassembly lineStructural basis of the adaptive molecular recognition by MMP9Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactionsStructures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism.Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumInvestigations on the maturation and regulation of archaebacterial proteasomesThe crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanismStructure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideumStructural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXaCrystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysisStructure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysisCrystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in CatalysisStructural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and TMechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulationCrystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological PropertiesSmall Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI)X-ray Structures of Human Furin in Complex with Competitive InhibitorsStructures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactionsReleasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding siteStructural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug designCloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergenPolycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment.Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity.Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase.Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.Molecular machines for protein degradation.A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.
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