Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
about
Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrityDNA polymerase delta is required for human mismatch repair in vitroMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Mechanisms of resistance to alkylating agentsTumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancerPCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsNuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsSomatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cellsStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDNA replication fidelity and cancerDNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancerEnhanced anti-tumor effect of zoledronic acid combined with temozolomide against human malignant glioma cell expressing O6-methylguanine DNA methyltransferaseNSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsSeparation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genesDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeA phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins.Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signalingResponsiveness of CPT-11 in respect to hMLH1 and hMSH2 protein expression in the primary colorectal cancer.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Mismatch repair mutants in yeast are not defective in transcription-coupled DNA repair of UV-induced DNA damage.Mismatch repair in correction of replication errors and processing of DNA damage.hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitroO6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer.Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy.The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cellsSurvival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.Biased short tract repair of palindromic loop mismatches in mammalian cellsEfficient repair of all types of single-base mismatches in recombination intermediates in Chinese hamster ovary cells. Competition between long-patch and G-T glycosylase-mediated repair of G-T mismatches.Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer.Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes.Serrated adenoma of the colorectum: a lesion with teethTrypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response.Is thymidine glycol containing DNA a substrate of E. coli DNA mismatch repair system?
P2860
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P2860
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
@en
type
label
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
@en
prefLabel
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
@en
P2093
P356
P1433
P1476
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
@en
P2093
P2888
P304
P356
10.1038/362652A0
P407
P577
1993-04-01T00:00:00Z
P6179
1050002420