Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
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PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma modelIdentification of egr1 direct target genes in the uterus by in silico analyses with expression profiles from mRNA microarray dataRemoval of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor.Versatile role of heparanase in inflammationIL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.Expressions of heparanase and upstream stimulatory factor in hepatocellular carcinoma.Mammalian heparanase: what is the message?Role of heparanase in radiation-enhanced invasiveness of pancreatic carcinoma.Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.Significance of heparanase in cancer and inflammation.FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.Heparanase: a target for drug discovery in cancer and inflammation.Heparan sulfate and heparanase as modulators of breast cancer progressionHeparanase in inflammation and inflammation-associated cancer.Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses.Simian virus 40 enhancer does not affect the tumor specificity of human heparanase gene promoter.Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Heparanase 1 involvement in prostate physiopathology.Heparanase is essential for the development of diabetic nephropathy in mice.Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.Characterization of mechanisms involved in secretion of active heparanase.PI-88 inhibits postoperative recurrence of hepatocellular carcinoma via disrupting the surge of heparanase after liver resection.Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.Repression of PDGF-R-α after cellular injury involves TNF-α, formation of a c-Fos-YY1 complex, and negative regulation by HDAC.Syndecan-1 and heparanase: potential markers for activity evaluation and differential diagnosis of Crohn's disease.Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway.Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation
P2860
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P2860
Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Early growth response gene 1 ( ...... transcription in tumor cells.
@en
type
label
Early growth response gene 1 ( ...... transcription in tumor cells.
@en
prefLabel
Early growth response gene 1 ( ...... transcription in tumor cells.
@en
P2093
P50
P356
P1476
Early growth response gene 1 ( ...... e transcription in tumor cells
@en
P2093
June R Hornby
Thura Soe-Htwe
P304
35136-35147
P356
10.1074/JBC.M503414200
P407
P577
2005-08-10T00:00:00Z