Heparanase: a target for drug discovery in cancer and inflammation.
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Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasionHeparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activityDengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to HyperpermeabilityFrom gene discovery to new biological mechanisms: heparanases and congenital urinary bladder diseaseInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesHeparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycansPG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma modelHeparanase regulates levels of syndecan-1 in the nucleus.Heparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationExon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.Extracellular matrix molecules: potential targets in pharmacotherapy.Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donorsA novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.Versatile role of heparanase in inflammationHeparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levelsDAMPening inflammation by modulating TLR signalling.Tumorigenic and adhesive properties of heparanase.Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.Discovery of novel sulfonated small molecules that inhibit vascular tube formationAllele loss and down-regulation of heparanase gene are associated with the progression and poor prognosis of hepatocellular carcinoma.Prognostic value of heparanase expression and cellular localization in oral cancer.Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo.PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical modelsPre-clinical and clinical significance of heparanase in Ewing's sarcoma.SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.Heparanase-1 activities in the development of laser induced choroidal neovascularization.In vitro and ex vivo evaluation of a multi-epitope heparinase vaccine for various malignancies.S-score: a scoring system for the identification and prioritization of predicted cancer genes.Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparinUrinary tract effects of HPSE2 mutations.Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich elementHeparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancerGekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factorSignificance of heparanase in cancer and inflammation.Heparanase levels are elevated in the plasma of pediatric cancer patients and correlate with response to anticancer treatmentIdentification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer ActivityHeparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation
P2860
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P2860
Heparanase: a target for drug discovery in cancer and inflammation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Heparanase: a target for drug discovery in cancer and inflammation.
@en
type
label
Heparanase: a target for drug discovery in cancer and inflammation.
@en
prefLabel
Heparanase: a target for drug discovery in cancer and inflammation.
@en
P2860
P356
P1476
Heparanase: a target for drug discovery in cancer and inflammation.
@en
P2093
E A McKenzie
P2860
P356
10.1038/SJ.BJP.0707182
P407
P577
2007-03-05T00:00:00Z