TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityHOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentProteostatic control of telomerase function through TRiC-mediated folding of TCAB1Finding the end: recruitment of telomerase to telomeresShort telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancyMultiple facets of TPP1 in telomere maintenanceStructure of Est3 reveals a bimodal surface with differential roles in telomere replicationTelomerase Regulation from Beginning to the EndCoilin: The first 25 yearsSingle-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulationModern genome editing meets telomeres: the many functions of TPP1The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityTelomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cellsInhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.Many disease-associated variants of hTERT retain high telomerase enzymatic activityInhibition of telomerase recruitment and cancer cell deathIdentification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancerTelomerase structure.Akt regulates TPP1 homodimerization and telomere protection.Telomerase enzymatic component hTERT shortens long telomeres in human cells.Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G1 cell cycle arrest in A549 cells.The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability.Regulated assembly and disassembly of the yeast telomerase quaternary complex.Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas.Telomere maintenance mechanisms in cancer: clinical implicationsInherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.Genetics of familial melanoma: 20 years after CDKN2A.Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorderStructure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsTRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
P2860
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P2860
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
TPP1 OB-fold domain controls t ...... telomerase to chromosome ends
@en
type
label
TPP1 OB-fold domain controls t ...... telomerase to chromosome ends
@en
prefLabel
TPP1 OB-fold domain controls t ...... telomerase to chromosome ends
@en
P2093
P2860
P1433
P1476
TPP1 OB-fold domain controls t ...... telomerase to chromosome ends
@en
P2093
Adam Freund
Andrew S Venteicher
Franklin L Zhong
Matthew F Pech
Steven E Artandi
P2860
P304
P356
10.1016/J.CELL.2012.07.012
P407
P577
2012-08-01T00:00:00Z