TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
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Mechanisms of FUS mutations in familial amyotrophic lateral sclerosisThe extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivoDysregulated axonal RNA translation in amyotrophic lateral sclerosisThe Function of Autophagy in Neurodegenerative DiseasesConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisThe function of RNA-binding proteins at the synapse: implications for neurodegenerationRNA-binding proteins in neurodegeneration: Seq and you shall receiveA loss of FUS/TLS function leads to impaired cellular proliferationEarly lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acidsEWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functionsA deep learning framework for modeling structural features of RNA-binding protein targets.Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stressAstrocytic TDP-43 pathology in Alexander diseaseTDP-43 suppresses tau expression via promoting its mRNA instability.GraphProt: modeling binding preferences of RNA-binding proteins.Functions of FUS/TLS from DNA repair to stress response: implications for ALS.The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinomaPur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.Targeting RNA binding proteins involved in neurodegeneration.ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.A network of RNA and protein interactions in Fronto Temporal Dementia.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.FUS/TLS contributes to replication-dependent histone gene expression by interaction with U7 snRNPs and histone-specific transcription factorsAltered mRNP granule dynamics in FTLD pathogenesis.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.TDP-43 and FUS en route from the nucleus to the cytoplasm.A deep boosting based approach for capturing the sequence binding preferences of RNA-binding proteins from high-throughput CLIP-seq data.Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutationsDivergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.Stress granules as crucibles of ALS pathogenesis.RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1RNA-mediated toxicity in neurodegenerative diseaseThe ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons.Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.
P2860
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P2860
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
TDP-43 and FUS RNA-binding pro ...... fate in motoneuron-like cells.
@en
type
label
TDP-43 and FUS RNA-binding pro ...... fate in motoneuron-like cells.
@en
prefLabel
TDP-43 and FUS RNA-binding pro ...... fate in motoneuron-like cells.
@en
P2093
P2860
P50
P356
P1476
TDP-43 and FUS RNA-binding pro ...... fate in motoneuron-like cells
@en
P2093
Antonia Ratti
Elisa Onesto
Francisco E Baralle
P2860
P304
15635-15647
P356
10.1074/JBC.M111.333450
P407
P577
2012-03-16T00:00:00Z