Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis.
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Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilizationBax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondriaNF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cellstBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cMAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domainsTumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19KInteraction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosisIdentification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosisBcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolMitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescenceApoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activationThe tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expressionCyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosisThe mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c releaseMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisMAP-1 is a mitochondrial effector of Bax.Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channelMitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.Hsp27 as a negative regulator of cytochrome C release.The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinaseReversible inhibition of Hsp70 chaperone function by Scythe and ReaperCaspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondriaRoles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosisCeramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cellsNLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species productionControl of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathwayCaspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosolProapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activityInduction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathwayXanthurenic acid translocates proapoptotic Bcl-2 family proteins into mitochondria and impairs mitochondrial functionMarine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreIntegration and oligomerization of Bax protein in lipid bilayers characterized by single molecule fluorescence studyStructural mechanism of Bax inhibition by cytomegalovirus protein vMIABH3-only proteins: a 20-year stock-takePutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Aspirin induces apoptosis through release of cytochrome c from mitochondriaRole of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells
P2860
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P2860
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Bid-induced conformational cha ...... me c release during apoptosis.
@en
type
label
Bid-induced conformational cha ...... me c release during apoptosis.
@en
prefLabel
Bid-induced conformational cha ...... me c release during apoptosis.
@en
P2093
P2860
P356
P1476
Bid-induced conformational cha ...... me c release during apoptosis.
@en
P2093
Antonsson B
Desagher S
Martinou JC
Maundrell K
Montessuit S
Osen-Sand A
P2860
P304
P356
10.1083/JCB.144.5.891
P407
P577
1999-03-01T00:00:00Z