The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.
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Epigenetic regulation by histone demethylases in hypoxiaHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionPotential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analysesACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1Small-molecular modulators of cancer-associated epigenetic mechanisms.The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesisSuccessful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation.Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases.Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice.Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.Context-specific regulation of cancer epigenomes by histone and transcription factor methylation.Cell cycle progression in response to oxygen levels.KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.JMJD1A promotes tumorigenesis and forms a feedback loop with EZH2/let-7c in NSCLC cells.SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity.The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity.The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis.SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.From biological mechanisms to clinical implications: the role of mineral dust-induced gene in lung cancers.Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α.KDM3A is not associated with metastasis and prognosis of breast cancer.RETRACTED: KDM3A confers metastasis and chemoresistance in epithelial ovarian cancerOverexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinomaProminent role of histone lysine demethylases in cancer epigenetics and therapy
P2860
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P2860
The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The JmjC domain-containing his ...... regulation of the HOXA1 gene.
@en
type
label
The JmjC domain-containing his ...... regulation of the HOXA1 gene.
@en
prefLabel
The JmjC domain-containing his ...... regulation of the HOXA1 gene.
@en
P2093
P2860
P356
P1476
The JmjC domain-containing his ...... regulation of the HOXA1 gene.
@en
P2093
Bruce A J Ponder
Gouji Toyokawa
Helen I Field
Hyun-Soo Cho
John D Kelly
Kazuhiro Maejima
Ken Masuda
Noriko Ikawa
Ryuji Hamamoto
Shinya Hayami
P2860
P304
P356
10.1002/IJC.26501
P577
2011-12-21T00:00:00Z