Functional regions of the human cytomegalovirus protein pUL97 involved in nuclear localization and phosphorylation of ganciclovir and pUL97 itself.
about
Human cytomegalovirus: challenges, opportunities and new drug developmentAntiviral drug resistance of human cytomegalovirus.Identification of inhibitors for a virally encoded protein kinase by 2 different screening systems: in vitro kinase assay and in-cell activity assay.Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesisRecombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase.Epstein-Barr virus protein kinase BGLF4 targets the nucleus through interaction with nucleoporins.Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir.Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxiaExpression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibilityCytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments.Comparison between human cytomegalovirus pUL97 and murine cytomegalovirus (MCMV) pM97 expressed by MCMV and vaccinia virus: pM97 does not confer ganciclovir sensitivity.Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovirAmino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation.The duck enteritis virus early protein, UL13, found in both nucleus and cytoplasm, influences viral replication in cell culture.Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis.The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 proteinEarly selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.Resistance of human cytomegalovirus to cyclopropavir maps to a base pair deletion in the open reading frame of UL97.Genotyping cytomegalovirus UL97 mutations by high-resolution melting analysis with unlabeled probe.
P2860
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P2860
Functional regions of the human cytomegalovirus protein pUL97 involved in nuclear localization and phosphorylation of ganciclovir and pUL97 itself.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Functional regions of the huma ...... ganciclovir and pUL97 itself.
@en
type
label
Functional regions of the huma ...... ganciclovir and pUL97 itself.
@en
prefLabel
Functional regions of the huma ...... ganciclovir and pUL97 itself.
@en
P2093
P1476
Functional regions of the huma ...... ganciclovir and pUL97 itself.
@en
P2093
Heuschmid M
Mühlberger D
Schaarschmidt P
Simoncini L
Wunderlich K
Zimmermann A
P304
P356
10.1099/0022-1317-79-9-2105
P407
P478
79 ( Pt 9)
P577
1998-09-01T00:00:00Z