Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.
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The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolyticsLow-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptorsPWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in ratsSelective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligandsTrace fear conditioning involves hippocampal alpha5 GABA(A) receptorsα2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in miceBenzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in miceAmygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.An anxiety-like phenotype in mice selectively bred for aggression.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.Low dose acute alcohol effects on GABA A receptor subtypesAlcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding siteThe heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina IIGABA(A) receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5IA, an alpha5 selective cognition enhancer.Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Mathematical modeling of heterogeneous electrophysiological responses in human β-cellsParadoxical reactions to benzodiazepines in intravenous sedation: a report of 2 cases and review of the literature.The dynamic modulation of GABA(A) receptor trafficking and its role in regulating the plasticity of inhibitory synapses.Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitAnxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtypeRole of α1- and α2-GABA(A) receptors in mediating the respiratory changes associated with benzodiazepine sedation.Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomesDistinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin.The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZPhysiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?GABAA receptors: properties and trafficking.Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors.Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.GABAA receptors, anesthetics and anticonvulsants in brain development.A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysisGABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.
P2860
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P2860
Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Pharmacology of recombinant ga ...... point-mutated alpha-subunits.
@en
type
label
Pharmacology of recombinant ga ...... point-mutated alpha-subunits.
@en
prefLabel
Pharmacology of recombinant ga ...... point-mutated alpha-subunits.
@en
P2093
P2860
P1433
P1476
Pharmacology of recombinant ga ...... y point-mutated alpha-subunits
@en
P2093
P2860
P304
P356
10.1016/S0014-5793(98)00803-5
P407
P50
P577
1998-07-01T00:00:00Z