RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
about
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityMolecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) couplingAbundance and stability of complexes containing inactive G protein-coupled receptors and G proteinsThe GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunitsRegulator of G Protein Signaling 2: A Versatile Regulator of Vascular Functionμ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacologyStructural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq ComplexGenome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent mannerDecreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulationRGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneuronsRGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signalingRegulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.Mining protein loops using a structural alphabet and statistical exceptionalityThe evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining.Novel peptide ligands of RGS4 from a focused one-bead, one-compound library.Upregulation of regulator of G-protein signaling 2 in the sclera of a form deprivation myopic animal modelIntracellular interactions of umeclidinium and vilanterol in human airway smooth muscle.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling.The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.The α1-adrenergic receptors: diversity of signaling networks and regulationReversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortexβ2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoidsHow regulators of G protein signaling achieve selective regulation.Active Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane.Protein-protein interactions at the adrenergic receptors.Is RGS-2 a new drug development target in cardiovascular disease?G-protein signaling: back to the futureA finer tuning of G-protein signaling through regulated control of RGS proteins.Reduced-order modelling of biochemical networks: application to the GTPase-cycle signalling moduleDelineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteinsR4 RGS proteins: regulation of G-protein signaling and beyond.The G protein-coupled receptors: pharmacogenetics and disease.Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq.
P2860
Q24296968-25189E26-E3AA-4DFE-ABAC-FF313CDB8544Q24300492-1390AFF5-F47F-4641-9085-61CEE69B20B4Q24650552-646F232D-0732-4C64-8994-A5E57EB8E671Q24810130-DF234FDA-48AB-444C-B18F-902C6D74D801Q26823214-BFC020C5-52D8-445E-8BA8-10A18D943F4CQ26991859-68C820C6-5E61-4D49-B096-E6A2BAB86C96Q27676578-3C6358AA-F207-47E1-887A-1EECEE835D6FQ27931421-EC887B44-F2C8-4DE5-9DFD-20D55DCFD7D7Q28306219-7B0ADF19-35D2-4CFE-A88F-E7774172B4DBQ28479035-0AE6CB50-9404-41F9-9341-9C8E7A891B08Q28578625-FF5877DF-0C75-42AE-A010-CD59C4396414Q28580341-69D2D768-86A5-4D2A-BF7A-9E79CBC61BCCQ30010478-2C92AB89-5043-4538-910D-B07188D1F574Q30385373-7A0BEAB3-9B80-4E43-90E1-A50AC970BD67Q30397640-4171FED8-7964-41FE-A61C-2913A936A6C2Q30984841-D3E74631-4423-4725-B63E-FA1F9B2B3F05Q31134674-473C06E9-A7AA-489D-B3C2-325013506FD8Q33352950-FCC6CC66-5E47-427C-9E18-97FB53991275Q33864888-133F2550-482B-486E-AC3A-5F635760127BQ33884409-4E7B6E98-44D0-494D-95EA-408B36B1BB6BQ34198530-A38877AB-CE17-47EC-ACC3-981746407B2CQ34314895-33310A17-C34A-4FF5-A826-A0766E235F0CQ34411115-6C0B4513-3DF5-4C6C-BB1C-5F0BC855B17FQ34476637-11395C9B-6086-425B-8059-8A31798F89F1Q34991036-6307DB36-258E-4927-92C5-CB20DF37CE9EQ35113438-EF7230B9-1104-4A79-8CA8-C8AC30356ECFQ35497109-1C11406D-F254-4552-916D-3E7B101BCB71Q35607486-ACD00B44-8754-4056-844A-00160CE4ACE5Q35621371-46FA2B58-2F76-4042-8C3D-2AA257A1F2D5Q35652043-17261876-11F8-44A0-88F4-C764AF8DD52AQ35652829-FA2E2053-8B0A-48C7-B921-9959C84212E5Q35791490-B626F65A-73CC-4263-9C48-93C46B3CD842Q35842514-0A4A7AD8-CCAE-4EEB-8BCF-9852E80799E1Q36061579-D18B355C-2F58-4729-A2C5-4CD970753F4FQ36115328-21105DA9-EC81-4DBE-81E6-2E4ABC241F1BQ36160080-42548E77-8F57-49EA-8B68-F841E39771BEQ36173822-50F2B3B4-D5FB-47BF-AA47-E1D2144B5D33Q36301542-1E6F5CCC-4666-4B77-A05D-B09475BDFBA8Q36310854-B6E4CBE9-2532-4732-9E5D-CAD94B33E8FBQ36447378-2CC5E913-88EB-46BB-B883-8FF4A1C2D5CD
P2860
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
RGS2 binds directly and select ...... modulate Gq/11alpha signaling.
@en
type
label
RGS2 binds directly and select ...... modulate Gq/11alpha signaling.
@en
prefLabel
RGS2 binds directly and select ...... modulate Gq/11alpha signaling.
@en
P2093
P356
P1476
RGS2 binds directly and select ...... modulate Gq/11alpha signaling.
@en
P2093
Allan I Levey
Chris Hague
John R Hepler
Leah S Bernstein
Peter Chidiac
Suneela Ramineni
Wendy Cladman
P304
21248-21256
P356
10.1074/JBC.M312407200
P407
P577
2004-02-19T00:00:00Z