Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome.
about
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningR chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistanceAlterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristinStructure of a conserved RNA component of the peptidyl transferase centreA convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decayMapping functionally important motifs SPF and GGQ of the decoding release factor RF2 to the Escherichia coli ribosome by hydroxyl radical footprinting. Implications for macromolecular mimicry and structural changes in RF2A minihelix-loop RNA acts as a trans-aminoacylation catalyst.Orientation of the tRNA anticodon in the ribosomal P-site: quantitative footprinting with U33-modified, anticodon stem and loop domainsStaphylococcus aureus domain V functions in Escherichia coli ribosomes provided a conserved interaction with domain IV is restoredInterference probing of rRNA with snoRNPs: a novel approach for functional mapping of RNA in vivoAn in vitro evolved precursor tRNA with aminoacylation activityExpanded versions of the 16S and 23S ribosomal RNA mutation databases (16SMDBexp and 23SMDBexp)Analysis of the active site of the ribosome by site-directed mutagenesis.The hybrid state of tRNA binding is an authentic translation elongation intermediateSpecific telomerase RNA residues distant from the template are essential for telomerase function.Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism.23S rRNA positions essential for tRNA binding in ribosomal functional sites.Ribozyme catalysis: not different, just worse.Active destruction of defective ribosomes by a ubiquitin ligase involved in DNA repair.Quality control of chemically damaged RNA.Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro.In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.Models of the elongation cycle: an evaluation.The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center.rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome.Ribosome protection by antibiotic resistance ATP-binding cassette protein.
P2860
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P2860
Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mutations at nucleotides G2251 ...... ferase center of the ribosome.
@en
type
label
Mutations at nucleotides G2251 ...... ferase center of the ribosome.
@en
prefLabel
Mutations at nucleotides G2251 ...... ferase center of the ribosome.
@en
P2093
P356
P1476
Mutations at nucleotides G2251 ...... ferase center of the ribosome.
@en
P2093
P356
10.1006/JMBI.1996.0780
P407
P577
1997-02-01T00:00:00Z