Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.
about
Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-alpha-hm-dT).Structural insights into RNA duplexes with multiple 2΄-5΄-linkages.Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages.Designing highly active siRNAs for therapeutic applications.Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistanceAntisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy.Recognition of nucleic acid double helices by homopyrimidine 2', 5'-linked RNA.Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics.CD, absorption and thermodynamic analysis of repeating dinucleotide DNA, RNA and hybrid duplexes [d/r(AC)]12.[d/r(GT/U)]12 and the influence of phosphorothioate substitution.Unimolecular antiparallel G-quadruplex folding topology of 2'-5'-isoTBA sequences remains unaltered by loop composition.
P2860
Q24814269-59120887-E545-40DB-BAAA-9C819391CD07Q30845087-10FB9879-7210-421D-9BF4-6C93C95D0F5DQ33601167-64267B72-A545-4FB8-BE47-4E163C6EADC8Q34644554-A7DA46DA-9BD4-423C-A21D-D4D5FFFEF0E9Q36254793-BF9E75BF-3734-4CA0-8B86-205E472DC7E0Q37189998-54673828-B240-42D5-A9EF-14789BA10505Q38290099-D72F8390-27AC-4220-A5A2-91372E830DA5Q38331419-C5AC355D-2064-412F-ABB8-491CFFE0DBC3Q38349059-50D098B3-F0D9-41FD-BEC6-2FA3F377BF59Q38504825-8353378B-E711-4A7E-AA4B-EA8B4F15D736Q39721395-6ADD1FE9-DEC8-4CC6-87BF-514CBC898533Q53662911-74C8F694-541D-4656-88B5-61E9D722E6B2
P2860
Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mixed backbone antisense oligo ...... -deoxyribonucleotide segments.
@en
type
label
Mixed backbone antisense oligo ...... -deoxyribonucleotide segments.
@en
prefLabel
Mixed backbone antisense oligo ...... -deoxyribonucleotide segments.
@en
P2093
P2860
P356
P1476
Mixed backbone antisense oligo ...... -deoxyribonucleotide segments.
@en
P2093
Kandimalla ER
Sasisekharan V
P2860
P304
P356
10.1093/NAR/25.2.370
P407
P577
1997-01-01T00:00:00Z