The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein.
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Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B)Store-independent activation of Orai1 by SPCA2 in mammary tumorsBinding of copper(I) by the Wilson disease protein and its copper chaperoneCopper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7ABiochemical basis of regulation of human copper-transporting ATPasesMolecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypesBiochemical characterization of P-type copper ATPasesStructure of a Copper Pump Suggests a Regulatory Role for Its Metal-Binding DomainThe Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational DockingCopper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxificationStructural biology of copper traffickingIn silico investigation of the ATP7B gene: insights from functional prediction of non-synonymous substitution to protein structure.The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylationDiverse functional properties of Wilson disease ATP7B variants.Tackling metal regulation and transport at the single-molecule level.Relating dynamic protein interactions of metallochaperones with metal transfer at the single-molecule levelCoordination chemistry of bacterial metal transport and sensing.Wilson's disease: a comprehensive review of the molecular mechanisms.Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).Evolution of copper transporting ATPases in eukaryotic organisms.Functional and Biochemical Characterization of Cucumber Genes Encoding Two Copper ATPases CsHMA5.1 and CsHMA5.2.HMA6 and HMA8 are two chloroplast Cu+-ATPases with different enzymatic properties.Toward a molecular understanding of metal transport by P(1B)-type ATPases.The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin.Expressional control of a cadmium-transporting P1B-type ATPase by a metal sensing degradation signal.An expanding range of functions for the copper chaperone/antioxidant protein Atox1.Calcium pumps in health and disease.Translocation of platinum anticancer drugs by human copper ATPases ATP7A and ATP7B.Human copper transporters: mechanism, role in human diseases and therapeutic potential.Mechanism of tumor resistance to cisplatin mediated by the copper transporter ATP7B.The MXCXXC class of metallochaperone proteins: model studies.The role of the Golgi-resident SPCA Ca²⁺/Mn²⁺ pump in ionic homeostasis and neural function.Molecular features of copper binding proteins involved in copper homeostasis.Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.Functional interactions of Cu-ATPase ATP7B with cisplatin and the role of ATP7B in the resistance of cells to the drug.The N-terminal metal-binding site 2 of the Wilson's Disease Protein plays a key role in the transfer of copper from Atox1.An NMR study of the interaction of the N-terminal cytoplasmic tail of the Wilson disease protein with copper(I)-HAH1.One gene, two proteins: coordinated production of a copper chaperone by differential transcript formation and translational frameshifting in Escherichia coli.Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.
P2860
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P2860
The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The distinct roles of the N-te ...... the Wilson's disease protein.
@en
type
label
The distinct roles of the N-te ...... the Wilson's disease protein.
@en
prefLabel
The distinct roles of the N-te ...... the Wilson's disease protein.
@en
P2860
P356
P1476
The distinct roles of the N-te ...... the Wilson's disease protein.
@en
P2093
Dominik Huster
Svetlana Lutsenko
P2860
P304
32212-32218
P356
10.1074/JBC.M305408200
P407
P577
2003-06-06T00:00:00Z