Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.
about
Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Phosphorylation events during viral infections provide potential therapeutic targets.Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses.
P2860
Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.
description
1996 nî lūn-bûn
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1996年の論文
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1996年学术文章
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1996年学术文章
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1996年学术文章
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1996年學術文章
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1996年學術文章
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name
Cyclin-dependent kinases phosp ...... and disrupt pRb-E2F complexes.
@en
type
label
Cyclin-dependent kinases phosp ...... and disrupt pRb-E2F complexes.
@en
prefLabel
Cyclin-dependent kinases phosp ...... and disrupt pRb-E2F complexes.
@en
P2093
P2860
P1433
P1476
Cyclin-dependent kinases phosp ...... and disrupt pRb-E2F complexes.
@en
P2093
P2860
P304
P407
P577
1996-05-01T00:00:00Z