Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
about
DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals.Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding.Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cellsSumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb.SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretionAldosterone induces clonal β-cell failure through glucocorticoid receptor.Inactivation of specific β cell transcription factors in type 2 diabetes.Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa.Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.Phosphorylation of MafA enhances interaction with Beta2/NeuroD1.SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function.The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α
P2860
Q33649512-4E0C09C3-9181-4179-9254-695A430DD0F4Q33800071-CCA91109-2D89-4FD9-BC7B-3453C7CDCB87Q33924202-CAE4C4B7-820B-4912-8977-032591D90CE3Q33961943-1F54F47F-9B08-48DF-AFF0-D7197342475EQ34055928-A957BA71-13B8-4577-9AD9-4F3506B04A0EQ34356005-B8648104-A7F2-4525-ACCF-E876CA1F84D2Q35420665-7BDBD8CE-4388-4E88-92A5-A734E6734242Q35849382-ECE3FAB0-6296-4057-AEB3-88E5B92F951CQ35969504-515CFDD0-2036-46A0-894F-C0ECC0F88BFCQ37052883-8DDACE4B-2526-4933-AB00-FE3BA31A79E1Q37163495-2F8CD9DE-3967-4527-9F96-512301C76661Q37509799-AF4E4CAB-AEC5-40A1-8133-D47FCC6A8B6BQ38001061-DA94FB61-815B-48E4-BE67-8AB6C79E6060Q38783022-133668CA-2C77-4074-8978-D0E0B79612B8Q41863831-DDEFF984-CE0E-4921-A986-CEE11EA0A036Q47233632-52A3B80C-7B35-4FFA-BFD5-98C42808D634Q58707539-0EC63C1B-F9CE-446E-AC52-D80CE4D9351E
P2860
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
@en
type
label
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
@en
prefLabel
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
@en
P2860
P356
P1476
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells.
@en
P2093
Chunli Shao
P2860
P304
P356
10.1074/JBC.M806286200
P407
P577
2008-11-22T00:00:00Z