Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells.
about
Thyroid malignant neoplasm-associated biomarkers as targets for oncolytic virotherapyRole of complex asparagine-linked oligosaccharides in the expression of a functional thyrotropin receptorThe ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitizationLimitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease.The hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice.Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes.Monoclonal antibodies to thyroid specific autoantigens.Role of asparagine-linked oligosaccharides in protein folding, membrane targeting, and thyrotropin and autoantibody binding of the human thyrotropin receptor.Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co-expressing MHC class II and thyroid autoantigens.Engineering the human thyrotropin receptor ectodomain from a non-secreted form to a secreted, highly immunoreactive glycoprotein that neutralizes autoantibodies in Graves' patients' sera.Subunit structure of thyrotropin receptors expressed on the cell surface.Antibodies to TSH-receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly distributed on the receptor.Induction of hyperthyroidism in mice by intradermal immunization with DNA encoding the thyrotropin receptor.An in vitro model based on cell monolayers grown on the underside of large- pore filters in bicameral chambers for studying thyrocyte-lymphocyte interactions.Residues 34-39 in the thyrotropin receptor are not the target of autoantibodies from sera of patients with Graves' disease.Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion.Induction of thyroiditis in mice with thyrotropin receptor lacking serologically dominant regions.Characterization of the murine immune response to the murine TSH receptor ectodomain: induction of hypothyroidism and TSH receptor antibodies.Characterisation of the antibody response to the extracellular region of recombinant thyrotropin receptor.
P2860
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P2860
Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Monoclonal antibodies to the h ...... e of thyroid follicular cells.
@en
type
label
Monoclonal antibodies to the h ...... e of thyroid follicular cells.
@en
prefLabel
Monoclonal antibodies to the h ...... e of thyroid follicular cells.
@en
P2093
P356
P1476
Monoclonal antibodies to the h ...... e of thyroid follicular cells.
@en
P2093
McGregor AM
Morgenthaler NG
Nicholson LB
P304
P356
10.1677/JME.0.0160159
P577
1996-04-01T00:00:00Z