Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.
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Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinHuman TAF(II)28 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activityPhysical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-YRole of Tax protein in human T-cell leukemia virus type-I leukemogenicityHuman T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation.The Role of HBZ in HTLV-1-Induced OncogenesisMolecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activationIn vivo rescue of a silent tax-deficient bovine leukemia virus from a tumor-derived ovine B-cell line by recombination with a retrovirally transduced wild-type tax gene.Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein.Phenolic fraction of tobacco smoke condensate potentiates benzo[a]pyerene diol epoxide-induced cell transformation: role of protein kinase C.Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-kappaB activation.Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Ternary complex factors and cofactors are essential for human T-cell leukemia virus type 1 tax transactivation of the serum response elementNF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ.KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation.Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300Human T-cell leukemia virus type 3 (HTLV-3) and HTLV-4 antisense-transcript-encoded proteins interact and transactivate Jun family-dependent transcription via their atypical bZIP motifChronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonismInsight into the tumor suppressor function of CBP through the viral oncoprotein tax.Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis.Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery.Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanismHuman T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signalingHuman T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisNF-kappaB and cancer: how intimate is this relationshipHuman T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability.Move or die: the fate of the Tax oncoprotein of HTLV-1.Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts.HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.Both wild-type and strongly attenuated bovine leukemia viruses protect peripheral blood mononuclear cells from apoptosis.The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
P2860
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P2860
Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Constitutive activation of NF- ...... emia virus type I Tax protein.
@en
type
label
Constitutive activation of NF- ...... emia virus type I Tax protein.
@en
prefLabel
Constitutive activation of NF- ...... emia virus type I Tax protein.
@en
P2093
P1433
P1476
Constitutive activation of NF- ...... emia virus type I Tax protein.
@en
P2093
Hatanaka M
Sugiyama T
P304
P407
P577
1996-02-01T00:00:00Z