Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. - Wikidata - wikimedia - TriplyDB

Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

http://www.wikidata.org/entity/Q38466630

about

Melanoma: from melanocyte to genetic alterations and clinical options Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?Pathways and therapeutic targets in melanoma Mitotic and mitogenic Wnt signalling Signaling cross-talk in the resistance to HER family receptor targeted therapy Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway Wnt/β-catenin signalling in prostate cancer WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.Cancer stem cells: a systems biology view of their role in prognosis and therapy Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.Evaluating melanoma drug response and therapeutic escape with quantitative proteomics Therapeutic effect of nanogel-based delivery of soluble FGFR2 with S252W mutation on craniosynostosis.Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields.Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail.SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling.Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling Wnt signaling in skin development, homeostasis, and disease.sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.In the Wnt-er of life: Wnt signalling in melanoma and ageing.Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.Mechanisms of RAS/β-catenin interactions.A Wnt-er migration: the confusing role of β-catenin in melanoma metastasis.MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells.Notch signaling in melanoma: interacting pathways and stromal influences that enhance Notch targeting.Developmental pathways activated in melanocytes and melanoma.LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.Customized chemotherapy in metastatic non-small cell lung cancer (NSCLC)

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Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

http://www.wikidata.org/entity/Q38466630

description

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name

Wnt/β-catenin signaling and AX ...... e BRAFV600E in human melanoma.

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type

label

Wnt/β-catenin signaling and AX ...... e BRAFV600E in human melanoma.

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prefLabel

Wnt/β-catenin signaling and AX ...... e BRAFV600E in human melanoma.

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Science Signaling

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Wnt/β-catenin signaling and AX ...... se BRAFV600E in human melanoma

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Andy J Chien

http://www.w3.org/2001/XMLSchema#string

David W Dawson

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Nick C Robin

http://www.w3.org/2001/XMLSchema#string

Olivia M Lucero

http://www.w3.org/2001/XMLSchema#string

Rachel A Toroni

http://www.w3.org/2001/XMLSchema#string

Reyna D Swift

http://www.w3.org/2001/XMLSchema#string

Richard G James

http://www.w3.org/2001/XMLSchema#string

Rima M Kulikauskas

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Travis L Biechele

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P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Bim: a novel member of the Bcl-2 family that promotes apoptosis

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Mutations of the BRAF gene in human cancer

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

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10.1126/SCISIGNAL.2002274

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206

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5

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Randall T. Moon

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2012-01-10T00:00:00Z

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221737962

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3297477

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