Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. - Wikidata - wikimedia - TriplyDB

Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

http://www.wikidata.org/entity/Q38485003

about

Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease Genetically engineered mouse models of Parkinson's disease The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Inhibition of microglia activation as a phenotypic assay in early drug discovery Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity Microglia development and function Low concentrations of methamphetamine can protect dopaminergic cells against a larger oxidative stress injury: mechanistic study Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation.Role of oxidative stress in Parkinson's disease.Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-α Release from Activated Microglia and TNF-α Converting Enzyme Activity The endotoxin-induced neuroinflammation model of Parkinson's disease.Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice.Autophagic impairment contributes to systemic inflammation-induced dopaminergic neuron loss in the midbrain.Association studies of MMP-9 in Parkinson's disease and amyotrophic lateral sclerosis.Expression of mutant alpha-synuclein modulates microglial phenotype in vitro α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant Transmission of Soluble and Insoluble α-Synuclein to Mice.The changing phenotype of microglia from homeostasis to disease Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan.microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

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Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

http://www.wikidata.org/entity/Q38485003

description

2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Alpha-synuclein activates micr ...... protease-activated receptor-1.

@en

type

label

Alpha-synuclein activates micr ...... protease-activated receptor-1.

@en

prefLabel

Alpha-synuclein activates micr ...... protease-activated receptor-1.

@en

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JIMMUNOL.0903480

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Journal of Immunology

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Alpha-synuclein activates micr ...... protease-activated receptor-1.

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P2093

Eun-Jung Lee

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Eunsung Junn

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Hee-Sun Kim

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In-Young Choi

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Moon-Chang Baek

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Moon-Sook Woo

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Pyong-Gon Moon

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Won-Ki Kim

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615-623

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scholarly article

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10.4049/JIMMUNOL.0903480

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1

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185

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2010-05-28T00:00:00Z

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44639003

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20511551

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