Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery
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Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolismPolyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefitsPhosphoinositides: tiny lipids with giant impact on cell regulationThe susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposingRare deleterious mutations of the gene EFR3A in autism spectrum disorders.New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi.Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila.Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.Target repurposing for neglected diseases.Proteases in malaria parasites - a phylogenomic perspective.Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposisEvolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.An evolutionary perspective of AMPK-TOR signaling in the three domains of life.The discovery of Foxl2 paralogs in chondrichthyan, coelacanth and tetrapod genomes reveals an ancient duplication in vertebrates.Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.Mechanism of substrate specificity of phosphatidylinositol phosphate kinases.Genome-wide analysis of the phosphoinositide kinome from two ciliates reveals novel evolutionary links for phosphoinositide kinases in eukaryotic cellsLipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexansClasses of phosphoinositide 3-kinases at a glance.When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules.Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.Computational Functional Analysis of Lipid Metabolic Enzymes.The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing.Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.An overview of quinoline as a privileged scaffold in cancer drug discovery.Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.Phylogenetic analysis of the diacylglycerol kinase family of proteins and identification of multiple highly-specific conserved inserts and deletions within the catalytic domain that are distinctive characteristics of different classes of DGK homologIdentification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role.Gene expression signatures and ex vivo drug sensitivity profiles in children with acute lymphoblastic leukemia.Plasmodial Kinase Inhibitors: License to Cure?Profiling of phosphatidylinositol 3-kinase (PI3K) proteins in insulin signaling pathway.
P2860
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P2860
Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Phylogenomics of phosphoinosit ...... r signaling and drug discovery
@en
type
label
Phylogenomics of phosphoinosit ...... r signaling and drug discovery
@en
prefLabel
Phylogenomics of phosphoinosit ...... r signaling and drug discovery
@en
P2860
P356
P1476
Phylogenomics of phosphoinosit ...... r signaling and drug discovery
@en
P2093
James R Brown
Kurt R Auger
P2860
P2888
P356
10.1186/1471-2148-11-4
P577
2011-01-05T00:00:00Z
P5875
P6179
1005212717