Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
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Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addictionDiscovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.Fragile X syndrome: an update on developing treatment modalities.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa."Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyOptimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
P2860
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P2860
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
@en
type
label
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
@en
prefLabel
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
@en
P2093
P2860
P1476
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS
@en
P2093
Alice L Rodriguez
C David Weaver
Richard Williams
P2860
P304
P356
10.1016/J.BMCL.2009.10.059
P407
P577
2009-10-28T00:00:00Z