Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. - Wikidata - wikimedia - TriplyDB

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

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Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273 Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.The antipsychotic potential of muscarinic allosteric modulation Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.Glutamatergic targets for enhancing extinction learning in drug addiction Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family.Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors.Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.Therapeutic potential of metabotropic glutamate receptor modulators.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.N-Acetylcysteine reverses cocaine-induced metaplasticity

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Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

http://www.wikidata.org/entity/Q30842826

description

2004 nî lūn-bûn

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2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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name

Discovery of positive alloster ...... ate receptor function in vivo.

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Discovery of positive alloster ...... ate receptor function in vivo.

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Discovery of positive alloster ...... ate receptor function in vivo.

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Discovery of positive alloster ...... ate receptor function in vivo.

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Discovery of positive alloster ...... ate receptor function in vivo.

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Discovery of positive alloster ...... ate receptor function in vivo.

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Journal of Medicinal Chemistry

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Discovery of positive alloster ...... ate receptor function in vivo.

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Cyrille Sur

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David D Wisnoski

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David L Williams

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Doug J Pettibone

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Gene G Kinney

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George D Hartman

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Joel R Huff

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Julie A O'brien

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Mark E Duggan

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Maryann Burno

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scholarly article

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10.1021/JM049400D

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24

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Craig W. Lindsley

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2004-11-01T00:00:00Z

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15537338

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