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Numerical modeling of oxygen distributions in cortical and cancellous bone: oxygen availability governs osteonal and trabecular dimensions.Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate.Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.Bone cell autophagy is regulated by environmental factors.Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria.Vancomycin bonded to bone grafts prevents bacterial colonizationOxygen tension regulates preosteocyte maturation and mineralization.The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis.RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis.Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation.Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function.Involvement of hydrogen peroxide in the differentiation and apoptosis of preosteoclastic cells exposed to arsenite.Transforming growth factor-beta1 (TGF-beta1) regulates ATDC5 chondrogenic differentiation and fibronectin isoform expression.Ionizing radiation sensitizes bone cells to apoptosis.Chondrocyte apoptosis in development, aging and disease.Chondrocyte apoptosis increases with age in the articular cartilage of adult animals.Antibiotic modification of native grafts: improving upon nature's scaffolds.A novel short hairpin RNA (shRNA) expression system promotes Sox9-dependent gene silencing.Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin.Bacterial colonization of bone allografts: establishment and effects of antibiotics.Effect of functional end groups of silane self-assembled monolayer surfaces on apatite formation, fibronectin adsorption and osteoblast cell function.Bone cell survival in microgravity: evidence that modeled microgravity increases osteoblast sensitivity to apoptogens.Apoptosis and survival of osteoblast-like cells are regulated by surface attachment.Antibiotics for local delivery systems cause skeletal cell toxicity in vitro.Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis.The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection.Induction of apoptosis in skeletal tissues: phosphate-mediated chick chondrocyte apoptosis is calcium dependent.An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells.Covalently attached vancomycin provides a nanoscale antibacterial surface.Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis.Vancomycin bound to Ti rods reduces periprosthetic infection: preliminary study.Vancomycin covalently bonded to titanium alloy prevents bacterial colonization.Active caspase-3 is required for osteoclast differentiationDevelopment of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activationMatrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ionsInorganic phosphate induces apoptosis of osteoblast-like cells in cultureCartilage viability after repetitive loading: a preliminary reportIn situ oxygen utilization in the rat intervertebral discCovalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonizationGram-Negative Bacteria Are Internalized Into Osteocyte-Like Cells
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P50
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Christopher S. Adams
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