Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.
about
Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiologyMechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channelsModern concepts concerning the origin of the heartbeat.The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeatInositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes.A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells.A paradigm shift for the heart's pacemaker.Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.Expression and distribution of voltage-gated ion channels in ferret sinoatrial nodeComplete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.The mitochondrial uniporter controls fight or flight heart rate increases.Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.Modern perspectives on numerical modeling of cardiac pacemaker cellNumerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.RyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.What keeps us ticking: a funny current, a calcium clock, or both?Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cellsMechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity.Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes.Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.Genesis and regulation of the heart automaticity.Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes.CaMKII in sinoatrial node physiology and dysfunction.Where is it and how much? Mapping and quantifying elements in single cells.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels.Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange.Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.Editorial: Ca(2+) Signaling and Heart Rhythm.High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.Pacemaker activity in the insect (T. molitor) heart: role of the sarcoplasmic reticulum.Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current.Electrophysiological heterogeneity of pacemaker cells in rabbit intercaval region, including SA node: insights from recording multiple ion currents in each cell.Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase.Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".
P2860
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P2860
Fundamental importance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Fundamental importance of Na+- ...... n guinea-pig sino-atrial node.
@en
type
label
Fundamental importance of Na+- ...... n guinea-pig sino-atrial node.
@en
prefLabel
Fundamental importance of Na+- ...... n guinea-pig sino-atrial node.
@en
P2093
P2860
P1476
Fundamental importance of Na+- ...... n guinea-pig sino-atrial node.
@en
P2093
Derek A Terrar
Luke Sanders
Matthew Lowe
Paul A D Mattick
Stevan Rakovic
P2860
P304
P356
10.1113/JPHYSIOL.2005.100305
P407
P577
2006-01-19T00:00:00Z