Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.
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The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.The binding orientations of structurally-related ligands can differ; A cautionary noteHigh-affinity fluorescent ligands for the 5-HT(3) receptorThe binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptorsAllosteric activation of the 5-HT3AB receptor by mCPBG.A single amino acid determines the toxicity of Ginkgo biloba extracts.VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors.5-HT(3) receptors.Bacterially expressed human serotonin receptor 3A is functionally reconstituted in proteoliposomesThe 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.Discriminating between 5-HT₃A and 5-HT₃AB receptorsStructure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands.5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems.Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands.Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor.Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors.Prolonged inhibition of 5-HT₃ receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization.Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site.Approaching the 5-HT₃ receptor heterogeneity by computational studies of the transmembrane and intracellular domains.Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor.2Bs or not 2Bs: that is the question.Natural compounds boldine and menthol are antagonists of human 5-HT3receptors: implications for treating gastrointestinal disorders
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P2860
Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cysteine modification reveals ...... heteromeric 5-HT3AB receptors.
@en
type
label
Cysteine modification reveals ...... heteromeric 5-HT3AB receptors.
@en
prefLabel
Cysteine modification reveals ...... heteromeric 5-HT3AB receptors.
@en
P2093
P2860
P1476
Cysteine modification reveals ...... heteromeric 5-HT3AB receptors.
@en
P2093
A J Thompson
S C R Lummis
P2860
P304
P356
10.1113/JPHYSIOL.2011.208439
P407
P577
2011-06-27T00:00:00Z